ABSTRACT
A hospital-based, pair-matched, case control study was carried out at Government Medical College Hospital, Nagpur to estimate the effectiveness of BCG vaccination in the prevention of pulmonary tuberculosis. The study included 412 incident cases of pulmonary tuberculosis, which were born onwards 1962. Each case was pair-matched with one control for age, sex and socio-economic status. Controls were selected from subjects attending study hospital for conditions other than tuberculosis and leprosy. The significant protective association between BCG vaccination and pulmonary tuberculosis was observed (OR = 0.47, 95% CI = 0.35-0.63). The overall vaccine effectiveness was 53% (36.5-65.3%). BCG vaccine was non-significantly more effective in age less than or equal to 20 years, among males and in upper and middle socio-economic stratum. The overall prevented fraction was estimated to be 38.6% (24.2-43.6%). Results of this study, thus, demonstrated a moderate effectiveness of BCG vaccination in prevention of pulmonary tuberculosis in study population.
Subject(s)
Adult , BCG Vaccine/immunology , Case-Control Studies , Female , Humans , Male , Odds Ratio , Socioeconomic Factors , Tuberculosis, Pulmonary/immunology , VaccinationABSTRACT
A hospital-based, pair matched, case control study was carried out to estimate the effectiveness of BCG vaccination in the prevention of childhood pulmonary tuberculosis. The study included 126 incident cases of pulmonary tuberculosis (diagnosed by WHO criteria) below/equal the age of 12 years. Each case was pair matched with one control for age, sex, socio-economic status. Controls were selected from subjects attending study hospital for conditions other than tuberculosis and leprosy. The significant protective association between BCG and childhood pulmonary tuberculosis was observed (OR = 0.39, 95% CI = 0.22, 0.68). The overall vaccine effectiveness was 61% (95% CI = 32%, 78%). BCG was nonsignificantly more effective in underfives, among males and in upper-middle socioeconomic strata. The overall prevented fraction was estimated to be 47.53% (95% CI = 21.41%, 67.25%). Results of this study thus demonstrated a moderate effectiveness of BCG vaccination in prevention of childhood pulmonary tuberculosis in a Central India population.
Subject(s)
Age Factors , BCG Vaccine , Case-Control Studies , Child , Child, Preschool , Confidence Intervals , Female , Humans , India/epidemiology , Infant , Male , Odds Ratio , Prevalence , Sex Factors , Socioeconomic Factors , Tuberculosis, Pulmonary/epidemiologyABSTRACT
A hospital-based pair-matched case-control study was performed at Government Medical College Hospital, Nagpur, to estimate the effectiveness of Bacillus Calmette Guerin (BCG) vaccination against genital tuberculosis. The study included 48 cases of genital tuberculosis in the age group of 21-34 years and an equal number of controls, matched for age and socioeconomic status. The estimates of vaccine effectiveness and prevented fraction were higher for the subjects in the age group of 21-30 years and subjects from middle strata of socioeconomic class. The overall vaccine effectiveness and prevented fraction was estimated to be 75 (38.85-89.79) and 49.99 (17.46-74.55) per cent respectively. Results of this study thus indicate that BCG vaccination is effective against genital tuberculosis.